Jacksonville, Florida, mayor Lenny Curry confirmed on Twitter late Friday night that an airplane has gone down in a river and all lives have been accounted for.
Curry also confirmed that more than 100 people were on board the flight.
Curry said that fire and rescue were on the scene and working to contain any contamination into the river.
WJXT-TV confirmed that 142 people were on board the Boeing 737 that was in the river. The station also confirmed that the plane had skidded off the runway before coming to a rest in the river.
Naval Air Station Jacksonville confirmed to local media that the flight originated from the US base located at Guantanamo Bay, Cuba.